Conditions for Setting the DTC
WARNING: This page does not describe the selected car, but rather 8 other vehicles, including the 2012 GMC Yukon XL, 2012 GMC Yukon, 2012 Chevrolet Tahoe, 2012 Chevrolet Suburban, and 2012 Chevrolet Avalanche. However, it is still accessible from the selected car via links, so may be relevant.
DTC P0300
The ECM is detecting a crankshaft speed change indicating a random misfire is occurring that exceeds mandated emission level standards or is at catalytic converter damaging levels.
DTC P0301, P0302, P0303, P0304, P0305, P0306, P0307, or P0308
The ECM is detecting a crankshaft speed change indicating a single cylinder misfire is occurring that exceeds mandated emission level standards or is at catalytic converter damaging levels.