DTC P0300
WARNING: This page is about a different car, the 2010 GMC Sierra, 2010 GMC Cab & Chassis Sierra, 2010 Chevrolet Silverado, and 2010 Chevrolet Cab & Chassis Silverado. However, it is still accessible from the selected car via links, so may be relevant.
The ECM is detecting a crankshaft speed change indicating a random misfire is occuring that exceeds mandated emission level standards or is at catalytic converter damaging levels.