Conditions for Setting the DTC
WARNING: This page is about a different car, the 2019 Chevrolet Malibu. However, it is still accessible from the selected car via links, so may be relevant.
P00B7
Engine Coolant Temperature Sensor & Radiator Coolant Temperature Sensor = Not within 40°C (72°F) of each other - For greater than 30 s
P0597, P0598, P0599
Control Circuit = Commanded state does not match the actual state - For greater than 15 s
P2181
E41 Engine Coolant Thermostat Heater = Stuck Open - For greater than 4 min