Conditions for Setting the DTC
WARNING: This page is about a different car, the 2016 GMC Acadia, 2016 Chevrolet Traverse, and 2016 Buick Enclave. However, it is still accessible from the selected car via links, so may be relevant.
P0300
The ECM detects a crankshaft rotation speed variation indicating a misfire rate sufficient to cause emissions levels to exceed a predetermined value or a misfire rate high enough to cause catalyst damage.
P0301, P0302, P0303, P0304, P0305, or P0306
The ECM detects a crankshaft rotation speed variation indicating a single cylinder misfire rate sufficient to cause emissions levels to exceed mandated standards.