Diagnostic Aids

WARNING: This page is about a different car, the 2016 GMC Acadia, 2016 Chevrolet Traverse, and 2016 Buick Enclave. However, it is still accessible from the selected car via links, so may be relevant.

This DTC may be set with a misfire DTC, however the existence of this DTC is a higher priority and indicates the condition to diagnose is related to fuel and/or injectors, not the ignition/spark system.
A restricted fuel injector may cause this DTC to set.
High resistance in the circuits of the fuel injectors could set this DTC without setting a Fuel Injector DTC. Test the fuel injector circuits of the affected cylinders for a high resistance if you suspect a condition.
A drop in system voltage during cold start may set this DTC.